Application: Fasting Mimetics and Longevity
DESCRIPTION:
Deriving from the ashitaba plant, 3,4-dimethoxychalcone (Also known as DMC) is a natural compound that can aid in the reversing of the effects of aging. By encouraging ‘cleansing and recycling’ of cells, unwanted and harmful cells built up over time are removed from the body.
RESEARCH:
Caloric restriction mimetics (CRMs) are compounds that mimic the health‐promoting and longevity‐extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux.
Autophagy is the process that breaks down parts of your cells in order to recycle them in the creation of new cells and cell products. Autophagy has important effects that occur both within the cell and outside of the cell. Autophagy aids in the decreasing of oxidative stress, increase of genomic stability (which aids in the prevention of cancer), increase in metabolism, and increase in the elimination of waste.
Information provided for educational purposes only. No therapeutic claims are made for the products or ingredients described.
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Further reading:
Zhang T, Yamashita Y, Yasuda M, Yamamoto N, Ashida H. Ashitaba (Angelica keiskei) extract prevents adiposity in high-fat diet-fed C57BL/6 mice. Food Funct. 2015;6(1):135-145. doi:10.1039/c4fo00525b
Ohkura N, Atsumi G, Ohnishi K, Baba K, Taniguchi M. Possible antithrombotic effects of Angelica keiskei (Ashitaba). Pharmazie. 2018;73(6):315-317. doi:10.1691/ph.2018.8370
Shimizu E, Hayashi A, Takahashi R, Aoyagi Y, Murakami T, Kimoto K. Effects of angiotensin I-converting enzyme inhibitor from Ashitaba (Angelica keiskei) on blood pressure of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 1999;45(3):375-383. doi:10.3177/jnsv.45.375
Enoki T, Ohnogi H, Nagamine K, et al. Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei. J Agric Food Chem. 2007;55(15):6013-6017. doi:10.1021/jf070720q
Tamyra Comeaux, MD 
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